This lecture highlights the oral cavity’s vital role in the early detection of systemic diseases. Through real clinical cases, attendees will learn how oral findings have revealed autoimmune, hematologic, and infectious disorders. Dr. Charmelo Silva emphasizes the bidirectional link between oral and systemic health, underscoring the importance of comprehensive oral exams. Dentists and oral health providers often identify early signs of systemic illness, enabling timely interventions that can significantly improve patient outcomes and quality of life.