Substance use can significantly impact overall and oral health, often before obvious signs appear. Dental professionals are uniquely positioned to recognize warning signs, initiate meaningful conversations and support early intervention. This course explores current trends in alcohol, cannabis, vaping, nicotine and other substances, along with their oral health implications. Attendees will learn practical screening and communication strategies and explore evidence-based pain management alternatives that reduce opioid reliance, helping them confidently support patients and improve outcomes.