Radiolucent lesions can range from benign to urgently concerning, making accurate recognition essential for clinicians interpreting dental radiographs. This course sheds light on the most common, most challenging and most easily misdiagnosed radiolucencies encountered in general practice. Through a structured, pattern-based approach, we review odontogenic and non-odontogenic lesions, cysts, tumors, infections and systemic conditions that may first present as radiolucencies on dental imaging. Learn how to evaluate borders, location, internal characteristics and effects on surrounding structures to narrow the differential diagnosis and determine appropriate next steps. Whether you’re looking to strengthen your radiographic interpretation skills or avoid common pitfalls, this session brings clarity to the shadows.